Objective: a-Glycerophosphocholine (GPC) is a putative acetylcholine precursor that potentially
increases growth hormone secretion through the action of acetylcholine-stimulated catecholamine.
The aim of this study was to investigate acute physiologic responses to a single intake of GPC.
Methods: Eight healthy male subjects (25 1 y old) ingested GPC 1000 mg or a placebo in
a double-blind randomized crossover study. Fasting blood samples were obtained before the
administration of GPC (baseline) and 60 and 120 min after administration. All subjects repeated the
identical protocol using the placebo.
Results: Plasma free choline levels significantly increased at 60 and 120 min after GPC administration.
Plasma growth hormone secretion was increased significantly 60 min after taking GPC,
whereas no significant change was observed with the placebo. In addition, the serum free fatty acid
was increased 120 min after GPC ingestion, but no changes were seen with the placebo. Moreover,
serum acetoacetate and 3-hydroxybutyrate levels, which are indices of hepatic fat oxidation, were
increased at 120 min after taking GPC, whereas the placebo had no effect.
Conclusion: These findings suggest that a single dose of GPC increases growth hormone secretion
and hepatic fat oxidation, with concomitant increases in choline levels, in young adults.
Studio completo: Glycerophosphocholine enhances growth hormone secretion 2012 Nutrition Kawamura.pdf
Il parere agli esperti
increases growth hormone secretion through the action of acetylcholine-stimulated catecholamine.
The aim of this study was to investigate acute physiologic responses to a single intake of GPC.
Methods: Eight healthy male subjects (25 1 y old) ingested GPC 1000 mg or a placebo in
a double-blind randomized crossover study. Fasting blood samples were obtained before the
administration of GPC (baseline) and 60 and 120 min after administration. All subjects repeated the
identical protocol using the placebo.
Results: Plasma free choline levels significantly increased at 60 and 120 min after GPC administration.
Plasma growth hormone secretion was increased significantly 60 min after taking GPC,
whereas no significant change was observed with the placebo. In addition, the serum free fatty acid
was increased 120 min after GPC ingestion, but no changes were seen with the placebo. Moreover,
serum acetoacetate and 3-hydroxybutyrate levels, which are indices of hepatic fat oxidation, were
increased at 120 min after taking GPC, whereas the placebo had no effect.
Conclusion: These findings suggest that a single dose of GPC increases growth hormone secretion
and hepatic fat oxidation, with concomitant increases in choline levels, in young adults.
Studio completo: Glycerophosphocholine enhances growth hormone secretion 2012 Nutrition Kawamura.pdf
Il parere agli esperti
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