Neuroendocrinology 1990 Sep;52(3):243-8
Effects of phosphatidylserine on the neuroendocrine response to physical stress in humans.
Monteleone P, Beinat L, Tanzillo C, Maj M, Kemali D.
The activity of brain cortex-derived phosphatidylserine (BC-PS) on the neuroendocrine and neurovegetative responses to physical stress was tested in 8 healthy men who underwent three experiments with a bicycle ergometer. According to a double-blind design, before starting the exercise, each subject received intravenously, within 10 min, 50 or 75 mg of BC-PS or a volume-matched placebo diluted in 100 ml of saline. Blood samples were collected before and after the exercise for plasma epinephrine (E), norepinephrine (NE), dopamine (DA), adrenocorticotropin (ACTH), cortisol, growth hormone (GH), prolactin (PRL) and glucose determinations. Blood pressure and heart rate were also recorded. Physical stress induced a clear-cut increase in plasma E, NE, ACTH, cortisol, GH and PRL, whereas no significant change was observed in plasma DA and glucose. Pretreatment with both 50 and 75 mg BC-PS significantly blunted the ACTH and cortisol responses to physical stress.
Travisando i risultati di questo studio, qualche ditta furbetta blaterava le miracolose virtù della fosfotidilserina (PS) nel contrastare il rilascio di cortisolo... in realtà nello studio non si utilizzano supplementi orali ma endovene!!!!
Allora direte ma è tutta una bufala? non proprio perchè un altro studio sempre di Monteleone verifica l'assunzione di PS assunta oralmente (800mg al dì) x 10 giorni ecco l'abstarct:
Eur J Clin Pharmacol 1992;42(4):385-8
Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men.
Monteleone P, Maj M, Beinat L, Natale M, Kemali D.
The effect of chronic administration of phosphatidylserine derived from brain cortex on the neuroendocrine responses to physical stress has been examined in a placebo-controlled study in 9 healthy men. Phosphatidylserine 800 mg/d for 10 days significantly blunted the ACTH and cortisol responses to physical exercise (P = 0.003 and P = 0.03, respectively), without affecting the rise in plasma GH and PRL. Physical exercise significantly increased the plasma lactate concentration both after placebo and phosphatidylserine. The results suggest that chronic oral administration of phosphatidylserine may counteract stress-induced activation of the hypothalamo-pituitary-adrenal axis in man.
Questo studio già è + vicino ad una reale supplementazione (ricordando il dosaggio di almeno 800 mg al dì!!!), però sempre in relazione a quello che qualche ditta furbetta afferma, non c'è nessun innalzamento dei livelli di GH, ma solo una discreta "barriera dui difesa" contro l'intake di cortisolo....
Per avere delle certezze sono necessari maggiori studi su un numero di campioni più ampio ed in particolare su atleti, che rispetto ai soggetti sedentari, presentano risposte allo stress diverse!
Concludendo i 200-400 mg di PS che suggeriscono per far aumentare i livelli di GH e ridurre il cortisolo, sono solo favolette
...
Bye
Effects of phosphatidylserine on the neuroendocrine response to physical stress in humans.
Monteleone P, Beinat L, Tanzillo C, Maj M, Kemali D.
The activity of brain cortex-derived phosphatidylserine (BC-PS) on the neuroendocrine and neurovegetative responses to physical stress was tested in 8 healthy men who underwent three experiments with a bicycle ergometer. According to a double-blind design, before starting the exercise, each subject received intravenously, within 10 min, 50 or 75 mg of BC-PS or a volume-matched placebo diluted in 100 ml of saline. Blood samples were collected before and after the exercise for plasma epinephrine (E), norepinephrine (NE), dopamine (DA), adrenocorticotropin (ACTH), cortisol, growth hormone (GH), prolactin (PRL) and glucose determinations. Blood pressure and heart rate were also recorded. Physical stress induced a clear-cut increase in plasma E, NE, ACTH, cortisol, GH and PRL, whereas no significant change was observed in plasma DA and glucose. Pretreatment with both 50 and 75 mg BC-PS significantly blunted the ACTH and cortisol responses to physical stress.
Travisando i risultati di questo studio, qualche ditta furbetta blaterava le miracolose virtù della fosfotidilserina (PS) nel contrastare il rilascio di cortisolo... in realtà nello studio non si utilizzano supplementi orali ma endovene!!!!
Allora direte ma è tutta una bufala? non proprio perchè un altro studio sempre di Monteleone verifica l'assunzione di PS assunta oralmente (800mg al dì) x 10 giorni ecco l'abstarct:
Eur J Clin Pharmacol 1992;42(4):385-8
Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men.
Monteleone P, Maj M, Beinat L, Natale M, Kemali D.
The effect of chronic administration of phosphatidylserine derived from brain cortex on the neuroendocrine responses to physical stress has been examined in a placebo-controlled study in 9 healthy men. Phosphatidylserine 800 mg/d for 10 days significantly blunted the ACTH and cortisol responses to physical exercise (P = 0.003 and P = 0.03, respectively), without affecting the rise in plasma GH and PRL. Physical exercise significantly increased the plasma lactate concentration both after placebo and phosphatidylserine. The results suggest that chronic oral administration of phosphatidylserine may counteract stress-induced activation of the hypothalamo-pituitary-adrenal axis in man.
Questo studio già è + vicino ad una reale supplementazione (ricordando il dosaggio di almeno 800 mg al dì!!!), però sempre in relazione a quello che qualche ditta furbetta afferma, non c'è nessun innalzamento dei livelli di GH, ma solo una discreta "barriera dui difesa" contro l'intake di cortisolo....
Per avere delle certezze sono necessari maggiori studi su un numero di campioni più ampio ed in particolare su atleti, che rispetto ai soggetti sedentari, presentano risposte allo stress diverse!
Concludendo i 200-400 mg di PS che suggeriscono per far aumentare i livelli di GH e ridurre il cortisolo, sono solo favolette
...Bye
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