l'anator è lontano anche ma in effetti....

[Ribosio80]

1: Nutr Rev. 2007 Mar;65(3):122-9. Links
Leucine and protein synthesis: mTOR and beyond.

• Stipanuk MH.

Division of Nutritional Sciences, 227 Savage Hall, Cornell University, Ithaca, NY 14853, USA. mhs6@cornell.edu
The effects of amino acid intake on protein synthesis in the intact rat appear to be mediated almost entirely by a single amino acid: leucine. The effect of leucine on protein synthesis appears to be closely associated with eIF4G phosphorylation and its association with eIF4E, but whether eIF4G phosphorylation actually mediates the effects of leucine or is merely associated with these events has not been elucidated. Additional research is needed to determine whether leucine effects eIF4G phosphorylation, whether eIF4G phosphorylation is essential for the effect of leucine on protein synthesis, and whether mTOR (mammalian target of rapamycin) or another component of the mTOR complex is somehow involved in leucine-specific signaling.
PMID: 17425063 [PubMed - indexed for MEDLINE]

[Ribosio80]

Biochem J. 2007 Apr 15;403(2):217-34. Links
Signalling to translation: how signal transduction pathways control the protein synthetic machinery.

• Proud CG.

Department of Biochemistry and Molecular Biology, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, Canada V6T 1Z3. cgpr@interchange.ubc.ca
Recent advances in our understanding of both the regulation of components of the translational machinery and the upstream signalling pathways that modulate them have provided important new insights into the mechanisms by which hormones, growth factors, nutrients and cellular energy status control protein synthesis in mammalian cells. The importance of proper control of mRNA translation is strikingly illustrated by the fact that defects in this process or its control are implicated in a number of disease states, such as cancer, tissue hypertrophy and neurodegeneration. Signalling pathways such as those involving mTOR (mammalian target of rapamycin) and mitogen-activated protein kinases modulate the phosphorylation of translation factors, the activities of the protein kinases that act upon them and the association of RNA-binding proteins with specific mRNAs. These effects contribute both to the overall control of protein synthesis (which is linked to cell growth) and to the modulation of the translation or stability of specific mRNAs. However, important questions remain about both the contributions of individual regulatory events to the control of general protein synthesis and the mechanisms by which the translation of specific mRNAs is controlled.
PMID: 17376031 [PubMed - indexed for MEDLINE]

[VinceGironda]

I pratica?

[Jester.Tear]

[tylerdurden84]

che cosa ci stai volendo dire?

[banned]

nn ho capito na ceppa

[pettone]

c'è qualche traduttorE in giro???