BAM (Bad Ass Mass)...qualcuno saprebbe spiegare la funzione dei componenti?

[Ospite]

http://www.musclenutrition.com/bam-bad-ass-mass.html

Quantità per dose ( 1 cap) : BAD Ass Mass si fa complessi: 575mg Olaoides Ptychopetalum Estratto, Basella Rubra Extract, (25R) - 5-alpha-spirostan-6-one-3b-ol, (25R) - 4-Spirosten-3b, 6b-doil.
Altri ingredienti: Stearato di magnesio, amido di granoturco modificato.

[brosgym]

Strano perche la basella viene usata come antivirale inibendo la sintesi proteica.....

[LARRY SCOTT]

Strano perche la basella viene usata come antivirale inibendo la sintesi proteica.....

Aahahahah realmente?

E gli steroli contenuti, hanno realmente qualche utilità?

[mr oat]

Strano perche la basella viene usata come antivirale inibendo la sintesi proteica.....

appunto..questo lo sapevo pure io...strano che si trova incluso..

per il resto ho sentito parlare molto bene della muira puama (il primo ingrediente) purtroppo sempre su topi, ma sembra essere comunque un ottimo "ingrediente"

Phytomedicine. 2010 Mar;17(3-4):248-53. doi: 10.1016/j.phymed.2009.07.001. Epub 2009 Aug 13.
Anti-stress effects of the "tonic"Ptychopetalum olacoides (Marapuama) in mice.

Piato AL, Detanico BC, Linck VM, Herrmann AP, Nunes DS, Elisabetsky E.
Source

Laboratório de Etnofarmacologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

Abstract

With the recognition that high levels of sustained stress are associated with the natural course of countless illnesses, effective anti-stress agents have gained importance. Improved endurance to particularly stressful periods is one of the medicinal claims for Marapuama (Ptychopetalum olacoides Bentham, PO), a popular Amazonian herbal. The purpose of this study was to evaluate if PO possesses anti-stress properties. To this end, an extract from PO (POEE) was evaluated on anxiety and glucose levels in mice submitted to the unpredictable chronic mild stress (UCMS) paradigm. POEE did not present anxiolytic effects, but was able to prevent (p<0.01) the UCMS-induced anxiety as assessed by the light/dark test (time spent in the lit area, POEE 100 and 300mg/kg 235.9+/-20.6s and 250.4+/-17.4s, respectively, compared to DMSO 104.7+/-24.4s). Likewise, although POEE did not induce noticeable effects on glycemia, it effectively (p<0.01) prevented the UCMS-induced hyperglycemia (POEE 100 and 300mg/kg 106.4+/-6.7mg/dl and 107.3+/-3.3mg/dl, respectively, compared to DMSO 134.6+/-5.9mg/dl). Additionally, POEE (50-200mg/kg i.p. and 800mg/kg p.o.) significantly (p<0.01 and p<0.05, respectively) increased the time to hypoxia-induced convulsion (by 38%, 51%, 59% and 27%, respectively for i.p. and p.o. treatments). The data indicate that POEE counteracts some of the effects brought about by chronic stress. This study combined with the identified antioxidant and neuroprotective properties, as well as the claimed benefits associated with stressful periods suggest that Ptychopetalum olacoides (Marapuama) might possess adaptogen-like properties.


Antioxidant activities of Ptychopetalum olacoides ("muirapuama") in mice brain.

Siqueira IR, Fochesatto C, Torres IL, da Silva AL, Nunes DS, Elisabetsky E, Netto CA.
Source

Departamento de Farmacologia, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500, sala 202, 90050-170 Porto Alegre RS, Brazil.

Abstract

Ptychopetalum olacoides (PO) roots are used by Amazonian peoples to prepare traditional remedies for treating various central nervous system conditions in which free radicals are likely to be implicated. Following the identification of PO ethanol extract (POEE) free-radical scavenging properties in vitro, the aim of this study was to verify the in vivo antioxidant effect of POEE. Aging mice (14 months) were treated (i.p.) with saline, DMSO (20%) or POEE (100mg/kg body wt.), and the hippocampi, cerebral cortex, striata, hypothalamus and cerebellum dissected out 60 min later to measure antioxidant enzyme activities, free-radical production and damage to macromolecules. POEE administration reduced free-radical production in the hypothalamus, lead to significant decrease in lipid peroxidation in the cerebral cortex, striatum and hypothalamus, as well as in the carbonyl content in cerebellum and striatum. In terms of antioxidant enzymes, catalase activity was increased in the cortex, striatum, cerebellum and hippocampus, while glutathione peroxidase activity was increased in the hippocampus. This study suggests that POEE contains compounds able to improve the cellular antioxidant network efficacy in the brain, ultimately reducing the damage caused by oxidative stress.

PMID: 17433649 [PubMed - indexed for MEDLINE

[mr oat]

questo poi per la basella rubra

New ribosome-inactivating proteins with polynucleotide:adenosine glycosidase and antiviral activities fromBasella rubra L. and bougainvillea spectabilis Willd.

Bolognesi A, Polito L, Olivieri F, Valbonesi P, Barbieri L, Battelli MG, Carusi MV, Benvenuto E, Del Vecchio Blanco F, Di Maro A, Parente A, Di Loreto M, Stirpe F.
Source

Dipartimento di Patologia Sperimentale dell'Università di Bologna, Italy.

Abstract

New single-chain (type 1) ribosome-inactivating proteins (RIPs) were isolated from the seeds of Basella rubra L. (two proteins) and from the leaves of Bougainvillea spectabilis Willd. (one protein). These RIPs inhibit protein synthesis both in a cell-free system, with an IC50 (concentration causing 50% inhibition) in the 10(-10) M range, and by various cell lines, with IC50S in the 10(-8)-10(-6) M range. All three RIPs released adenine not only from rat liver ribosomes but also from Escherichia coli rRNA, polyadenylic acid, herring sperm DNA, and artichoke mottled crinkle virus (AMCV) genomic RNA, thus being polynucleotide:adenosine glycosidases. The proteins from Basella rubra had toxicity to mice similar to that of most type 1 RIPs (Barbieri et al., 1993, Biochim Biophys Acta 1154: 237-282) with an LD50 (concentration that is 50% lethal) < or = 8 mg.kg-1 body weight, whilst the RIP from Bougainvillea spectabilis had an LD50 > 32 mg.kg-1. The N-terminal sequence of the two RIPs from Basella rubra had 80-93% identity, whereas it differed from the sequence of the RIP from Bougainvillea spectabilis. When tested with antibodies against various RIPs, the RIPs fromBasella gave some cross-reactivity with sera against dianthin 32, and weak cross-reactivity with momordin I and momorcochin-S, whilst the RIP from Bougainvillea did not cross-react with any antiserum tested. An RIP from Basella rubra and one from Bougainvillea spectabilis were tested for antiviral activity, and both inhibited infection of Nicotiana benthamiana by AMCV.





Effects of Basella alba and Hibiscus macranthus extracts on testosterone production of adult rat and bull Leydig cells

Paul F. Moundipa1, Nathalie Sara E. Beboyl, Fabien Zelefack2, Silvère Ngouela2, Etienne Tsamo2, Wolf-Bernhard Schill3, Thomas K. Monsees3,4

1Departments of Biochemistry and 2Organic Chemistry, University of Yaounde I, P. O. Box 812 Yaounde, Cameroon
3Centre for Dermatology and Andrology, Justus Liebig University, Gaffkystr.1435385 Giessen, Germany
4Department of Anatomy, University of Technology, Fetscherstr. 74, 01307 Dresden, Germany

Abstract

Aim: To determine the androgenic effects of Basella alba and Hibiscus macranthus extracts in the rat and the bull, and to develop a novel in vitro test system using Leydig cells from bull testes. Methods: The effect of methanol extracts from both plants on testosterone production in isolated Leydig cells from the rat and the bull was analyzed using 125I-radioimmunoassay (125I-RIA). Rat Leydig cells were obtained by common methods, whereas a novel technique was used to purify Leydig cells from bull testes. Results: Bull testes from the slaughter house were a cheap source of pure Leydig cells. In culture, these cells produced testosterone for 5-6 days, which can be stimulated by human chorionic gonadotrophin (hCG). Basella alba extracts significantly enhanced testosterone production in bull and rat Leydig cells in a concentration-dependent manner. Hibiscus macranthus showed no androgenic effect but was shown to inhibit testosterone production at higher concentrations. Conclusion: Leydig cells purified from bull testes can be used as an alternative tool in experimental animal research. Certain fractions of Basella alba extract demonstrated androgenic potential whereas Hibiscus macranthus extracts did not. (Asian J Androl 2005 Dec; 7: 411–417)

[xymox]

Mah...

[fenix91]

Aahahahah realmente?

E gli steroli contenuti, hanno realmente qualche utilità?

Se vuoi il mio parere, sono quasi del tutto inutili

[LARRY SCOTT]

Quindi un classico prodotto costoso con nomi altisonanti, ma totalmente inutile se non controproducente.
Grazie a tutti.

[mr oat]

Se vuoi il mio parere, sono quasi del tutto inutili

umh...forse perche sottodosati? a me non dispiace molto come prodotto

[LARRY SCOTT]

Nelle reviews anglosassoni leggo pareri molto contrastanti...chimicamente i due steroli che effetti dovrebbero espletare? Progestinici?

[Dado73]

Provato per un mese un anno fa (mi alleno da 20 anni e integro quasi dall'inizio).... su di me zero risultati, in compenso un principio di gine poi rientrato (naturalmente non ho la prova che sia dipeso da quest'integratore, ma il sospetto viene).