Curioso poi che non tutte le proteine diano lo stesso effetto sui reni. Alla faccia di Giovanni Cianti (perdonatemi la battuta) pare che le proteine dei latticini, albumi e soia “impattino” i reni in modo meno hard della carne.
J Am Diet Assoc. 2007 Apr;107(4):644-50.
Are high-protein, vegetable-based diets safe for kidney function? A review of the literature.
Bernstein AM, Treyzon L, Li Z.
Source
Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA.
Abstract
In individuals with chronic kidney disease, high-protein diets have been shown to accelerate renal deterioration, whereas low-protein diets increase the risk of protein malnutrition. Vegetarian diets have been promoted as a way to halt progression of kidney disease while maintaining adequate nutrition. We review the literature to date comparing the effects of animal and vegetable protein on kidney function in health and disease. Diets with conventional amounts of protein, as well as high-protein diets, are reviewed. The literature shows that in short-term clinical trials, animal protein causes dynamic effects on renal function, whereas egg white, dairy, and soy do not. These differences are seen both in diets with conventional amounts of protein and those with high amounts of protein. The long-term effects of animal protein on normal kidney function are not known. Although data on persons with chronic kidney disease are limited, it appears that high intake of animal and vegetable proteins accelerates the underlying disease process not only in physiologic studies but also in short-term interventional trials. The long-term effects of high protein intake on chronic kidney disease are still poorly understood. Several mechanisms have been suggested to explain the different effects of animal and vegetable proteins on normal kidney function, including differences in postprandial circulating hormones, sites of protein metabolism, and interaction with accompanying micronutrients.
I’iperfiltrazione, concetto vago (ma che ben si capisce se uno vuole) è quello che succede mangiando tante proteine. Non è uno stato “definito”, adesso sono in iperfiltrazione, tra un’ora non più. E’ una misura di quanto faccio lavorare i miei reni IN RAPPORTO a quanto possono lavorare al 100%.
E’ come fare 50 kg in panca con il massimale di 120 piuttosto che di 70. Per qualcuno 200 g di proteine metteranno i reni a duro lavoro, per altri no.
Sarà variabile da persona a persona.
In tutti però, se raddoppio le proteine introdotte, raddioppio (più o meno) la filtrazione, ovvero raddoppio il “lavoro dei reni”.
Ripeto e sottolineo che questo non significa necessariamente danno.
Am J Kidney Dis. 2004 Dec;44(6):950-62.
High-protein diets: potential effects on the kidney in renal health and disease.
Friedman AN.
Source
Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. allfried@iupui.edu
Abstract
High-protein (HP) weight-loss diets have existed in the United States for decades, although their popularity has recently surged as obesity has become more common. Despite their widespread use, valid concerns exist that HP diets may induce clinically important alterations in renal function and health. HP consumption has been found, under various conditions, to lead to glomerular hyperfiltration and hyperemia; acceleration of chronic kidney disease (CKD); increased proteinuria; diuresis, natriuresis, and kaliuresis with associated blood pressure changes; increased risk for nephrolithiasis; and various metabolic alterations. Unfortunately, a comprehensive understanding of the implications of HP diets is limited by the lack of a universally accepted definition for HP intake, a paucity of rigorous long-term human interventional studies that necessitate relying on short-term or fairly circumstantial evidence, and sparse data on the effects of HP consumption in obese individuals. In addition, matters are further complicated because the renal impact HP diets for limited periods is most likely different than that for more chronic consumption. Nevertheless, although there are no clear renal-related contraindications to HP diets in individuals with healthy kidney function, the theoretical risks should be reviewed carefully with the patient. In contrast, HP diets have the potential for significant harm in individuals with CKD and should be avoided if possible. Because CKD is often a silent disease, all individuals should undergo a screening serum creatinine measurement and urinary dipstick test for proteinuria before the initiation of such a diet.
A complicare le cose ci sono poi segnalazioni che anche le calorie siano in gioco nei possibili danni renali … e probabilmente ci saranno altre cose che non pensiamo…
Am J Nephrol. 1999;19(3):433-40.
A low-calorie unrestricted protein diet attenuates kidney damage in uninephrectomized spontaneously hypertensive rats.
Reisin E, Harris KY, Azar S, DeBoisblanc B, Thakur V, Liuzza GF.
Source
Department of Medicine, Louisiana State University, New Orleans, LA 70112-2822, USA.
Abstract
BACKGROUND/AIMS:
Uninephrectomized, spontaneously hypertensive rats (UNX-SHR) develop glomerular hyperfiltration, hyperfusion, and interstitial infiltrate of the remnant kidney. Consequently, UNX-SHR is a useful animal model to investigate mechanisms involved in the progression of hypertensive renal disease.
METHODS:
Body weight; tail systolic blood pressure (SBP); urine excretion of protein, urea, and electrolytes; and serum biochemistry were determined in UNX-SHR at 2 months of age prior to uninephrectomy (week 0), prior to treatment (week 8) with a low-calorie (LC) or control diet, and one month after diet treatment (week 12). The LC diet was modified to allow equal intake of protein, sodium phosphorus, and other nutrients in both groups.
RESULTS:
UNX-SHR treated with the LC diet had significantly lower body weights and SBP at the end of the experiment than did the controls (p < 0.0001). Changes in serum biochemistry and 24-hour urinary excretion of protein, sodium, potassium, and urea nitrogen in both groups were not statistically significant. The final glomerular filtration rate and renal plasma flow were similar in both groups, but the LC diet significantly reduced the glomerular damage index (0.0007), mesangial expansion index (p < 0.002), volume of interstitium per cortex (p < 0.0003), tubular interstitium volume fraction (p < 0.0008), glomerular volume (p < 0.02), and remnant kidney weight (p < 0.01).
CONCLUSION:
We demonstrated that in UNX-SHR, the prevention of renal damage by LC diet may involve diminished glomerular growth and interstitial infiltrate without changes in renal hemodynamics. Consequently, LC diet, regardless of protein ingestion, may be an important tool in the prevention of renal damage in hypertension. Additional studies of obese-hypertensive rats may confirm the beneficial effect of a LC diet and weight reduction on the renal damage of obesity-hypertension.
Personalmente anche dopo questa rinfrescata rimango con le mie conclusioni di prima.
Eagle
J Am Diet Assoc. 2007 Apr;107(4):644-50.
Are high-protein, vegetable-based diets safe for kidney function? A review of the literature.
Bernstein AM, Treyzon L, Li Z.
Source
Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA.
Abstract
In individuals with chronic kidney disease, high-protein diets have been shown to accelerate renal deterioration, whereas low-protein diets increase the risk of protein malnutrition. Vegetarian diets have been promoted as a way to halt progression of kidney disease while maintaining adequate nutrition. We review the literature to date comparing the effects of animal and vegetable protein on kidney function in health and disease. Diets with conventional amounts of protein, as well as high-protein diets, are reviewed. The literature shows that in short-term clinical trials, animal protein causes dynamic effects on renal function, whereas egg white, dairy, and soy do not. These differences are seen both in diets with conventional amounts of protein and those with high amounts of protein. The long-term effects of animal protein on normal kidney function are not known. Although data on persons with chronic kidney disease are limited, it appears that high intake of animal and vegetable proteins accelerates the underlying disease process not only in physiologic studies but also in short-term interventional trials. The long-term effects of high protein intake on chronic kidney disease are still poorly understood. Several mechanisms have been suggested to explain the different effects of animal and vegetable proteins on normal kidney function, including differences in postprandial circulating hormones, sites of protein metabolism, and interaction with accompanying micronutrients.
I’iperfiltrazione, concetto vago (ma che ben si capisce se uno vuole) è quello che succede mangiando tante proteine. Non è uno stato “definito”, adesso sono in iperfiltrazione, tra un’ora non più. E’ una misura di quanto faccio lavorare i miei reni IN RAPPORTO a quanto possono lavorare al 100%.
E’ come fare 50 kg in panca con il massimale di 120 piuttosto che di 70. Per qualcuno 200 g di proteine metteranno i reni a duro lavoro, per altri no.
Sarà variabile da persona a persona.
In tutti però, se raddoppio le proteine introdotte, raddioppio (più o meno) la filtrazione, ovvero raddoppio il “lavoro dei reni”.
Ripeto e sottolineo che questo non significa necessariamente danno.
Am J Kidney Dis. 2004 Dec;44(6):950-62.
High-protein diets: potential effects on the kidney in renal health and disease.
Friedman AN.
Source
Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. allfried@iupui.edu
Abstract
High-protein (HP) weight-loss diets have existed in the United States for decades, although their popularity has recently surged as obesity has become more common. Despite their widespread use, valid concerns exist that HP diets may induce clinically important alterations in renal function and health. HP consumption has been found, under various conditions, to lead to glomerular hyperfiltration and hyperemia; acceleration of chronic kidney disease (CKD); increased proteinuria; diuresis, natriuresis, and kaliuresis with associated blood pressure changes; increased risk for nephrolithiasis; and various metabolic alterations. Unfortunately, a comprehensive understanding of the implications of HP diets is limited by the lack of a universally accepted definition for HP intake, a paucity of rigorous long-term human interventional studies that necessitate relying on short-term or fairly circumstantial evidence, and sparse data on the effects of HP consumption in obese individuals. In addition, matters are further complicated because the renal impact HP diets for limited periods is most likely different than that for more chronic consumption. Nevertheless, although there are no clear renal-related contraindications to HP diets in individuals with healthy kidney function, the theoretical risks should be reviewed carefully with the patient. In contrast, HP diets have the potential for significant harm in individuals with CKD and should be avoided if possible. Because CKD is often a silent disease, all individuals should undergo a screening serum creatinine measurement and urinary dipstick test for proteinuria before the initiation of such a diet.
A complicare le cose ci sono poi segnalazioni che anche le calorie siano in gioco nei possibili danni renali … e probabilmente ci saranno altre cose che non pensiamo…
Am J Nephrol. 1999;19(3):433-40.
A low-calorie unrestricted protein diet attenuates kidney damage in uninephrectomized spontaneously hypertensive rats.
Reisin E, Harris KY, Azar S, DeBoisblanc B, Thakur V, Liuzza GF.
Source
Department of Medicine, Louisiana State University, New Orleans, LA 70112-2822, USA.
Abstract
BACKGROUND/AIMS:
Uninephrectomized, spontaneously hypertensive rats (UNX-SHR) develop glomerular hyperfiltration, hyperfusion, and interstitial infiltrate of the remnant kidney. Consequently, UNX-SHR is a useful animal model to investigate mechanisms involved in the progression of hypertensive renal disease.
METHODS:
Body weight; tail systolic blood pressure (SBP); urine excretion of protein, urea, and electrolytes; and serum biochemistry were determined in UNX-SHR at 2 months of age prior to uninephrectomy (week 0), prior to treatment (week 8) with a low-calorie (LC) or control diet, and one month after diet treatment (week 12). The LC diet was modified to allow equal intake of protein, sodium phosphorus, and other nutrients in both groups.
RESULTS:
UNX-SHR treated with the LC diet had significantly lower body weights and SBP at the end of the experiment than did the controls (p < 0.0001). Changes in serum biochemistry and 24-hour urinary excretion of protein, sodium, potassium, and urea nitrogen in both groups were not statistically significant. The final glomerular filtration rate and renal plasma flow were similar in both groups, but the LC diet significantly reduced the glomerular damage index (0.0007), mesangial expansion index (p < 0.002), volume of interstitium per cortex (p < 0.0003), tubular interstitium volume fraction (p < 0.0008), glomerular volume (p < 0.02), and remnant kidney weight (p < 0.01).
CONCLUSION:
We demonstrated that in UNX-SHR, the prevention of renal damage by LC diet may involve diminished glomerular growth and interstitial infiltrate without changes in renal hemodynamics. Consequently, LC diet, regardless of protein ingestion, may be an important tool in the prevention of renal damage in hypertension. Additional studies of obese-hypertensive rats may confirm the beneficial effect of a LC diet and weight reduction on the renal damage of obesity-hypertension.
Personalmente anche dopo questa rinfrescata rimango con le mie conclusioni di prima.
Eagle
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