ovviamente ora mi son flippato con pubmed e sto sclerando dietro a calcio e caffeina....
ho trovato un po di studi che confermano cio' che pensavo.
un po di studi.
comincio.
Mechanisms of dairy modulation of adiposity.
Zemel MB.
Department of Nutrition, The University of Tennessee, Knoxville 37996, USA. mzemel@utk.edu
Dietary calcium plays a pivotal role in the regulation of energy metabolism, in that we have found high calcium diets to attenuate adipocyte lipid accretion and weight gain during periods of overconsumption of an energy-dense diet and to increase lipolysis and preserve thermogenesis during caloric restriction, thereby markedly accelerating weight loss. Our studies of the agouti gene in obesity and insulin resistance demonstrate a key role for intracellular Ca(2+) in regulating adipocyte lipid metabolism and triglyceride storage, with increased intracellular Ca(2+), resulting in stimulation of lipogenic gene expression and lipogenesis, and suppression of lipolysis, resulting in adipocyte lipid filling and increased adiposity. Moreover, we have recently demonstrated that the increased calcitriol produced in response to low calcium diets stimulates Ca(2+) influx in human adipocytes and thereby promotes adiposity. Accordingly, suppressing calcitriol levels by increasing dietary calcium is an attractive target for the prevention and management of obesity. In support of this concept, transgenic mice expressing the agouti gene specifically in adipocytes (a humanlike pattern) respond to low calcium diets with accelerated weight gain and fat accretion, whereas high calcium diets markedly inhibit lipogenesis, accelerate lipolysis, increase thermogenesis and suppress fat accretion and weight gain in animals maintained at identical caloric intakes. Further, low calcium diets impede body fat loss, whereas high calcium diets markedly accelerate fat loss in transgenic mice subjected to caloric restriction. Notably, dairy sources of calcium exert markedly greater effects in attenuating weight and fat gain and accelerating fat loss. This augmented effect of dairy vs. supplemental calcium is likely attributable to additional bioactive compounds in dairy that act synergistically with calcium to attenuate adiposity; among these are angiotensin converting enzyme inhibitory peptides, which limit angiotensin II production and thereby limit angiotensin II stimulation of adipocyte lipogenesis. These concepts are confirmed by both epidemiological and clinical data, which similarly demonstrate that dairy products exert a substantially greater effect on both fat loss and fat distribution compared to an equivalent amount of supplemental calcium.
Publication Types:
Review
Review, Tutorial
PMID: 12514303 [PubMed - indexed for MEDLINE]
in pratica: diete con alto introito di calcio favoriscono termogenesi e lipolisi bloccando la lipogenesi.
nella seconda parte spiega che assumendo alimenti ricchi di calcio (I LATTICINI CHE MOLTI LEVANO IN DEFINIZIONE) si ha un effetto lipolitico della madonna, riscontrato in maniera minore se si integra.
Ne avevo trovati altri ma grazie ai continui messaggi di joe li ho persi.
in poche parole:
- su con il calcio!!!!
- assumere latticini, e cmq prodotti ad alto contenuto di calcio aiuta il dimagrimento e non poco, al di la dell'eventuale ritenzione (che tanto chi ***** se ne freca.)
- l'integrazione di calcio co pasticche pasticcone non e' efficace come con gli alimenti grazie alla presenza di enzimi
- assumere calcio c'e' da farlo lontano da fonti di caffeina che ne inibirebbe l'assorbimento
- viceversa, assumere multivitaminici multiminerali lontano dal calcio perche il calcio stesso ne limiterebbe l'abs.
- ci sono gli studi anche sulle persone e non solo sui topi...
- c'e' uno studio che dice che le diete iperproteiche portano alla deplezione de calcio... quindi assumerlo non puo' fare che bene
- e non solo! il calcio combatte pure L'INSULINO RESISTENZA!
... daje dentro co la vanetta
ho trovato un po di studi che confermano cio' che pensavo.
un po di studi.
comincio.
Mechanisms of dairy modulation of adiposity.
Zemel MB.
Department of Nutrition, The University of Tennessee, Knoxville 37996, USA. mzemel@utk.edu
Dietary calcium plays a pivotal role in the regulation of energy metabolism, in that we have found high calcium diets to attenuate adipocyte lipid accretion and weight gain during periods of overconsumption of an energy-dense diet and to increase lipolysis and preserve thermogenesis during caloric restriction, thereby markedly accelerating weight loss. Our studies of the agouti gene in obesity and insulin resistance demonstrate a key role for intracellular Ca(2+) in regulating adipocyte lipid metabolism and triglyceride storage, with increased intracellular Ca(2+), resulting in stimulation of lipogenic gene expression and lipogenesis, and suppression of lipolysis, resulting in adipocyte lipid filling and increased adiposity. Moreover, we have recently demonstrated that the increased calcitriol produced in response to low calcium diets stimulates Ca(2+) influx in human adipocytes and thereby promotes adiposity. Accordingly, suppressing calcitriol levels by increasing dietary calcium is an attractive target for the prevention and management of obesity. In support of this concept, transgenic mice expressing the agouti gene specifically in adipocytes (a humanlike pattern) respond to low calcium diets with accelerated weight gain and fat accretion, whereas high calcium diets markedly inhibit lipogenesis, accelerate lipolysis, increase thermogenesis and suppress fat accretion and weight gain in animals maintained at identical caloric intakes. Further, low calcium diets impede body fat loss, whereas high calcium diets markedly accelerate fat loss in transgenic mice subjected to caloric restriction. Notably, dairy sources of calcium exert markedly greater effects in attenuating weight and fat gain and accelerating fat loss. This augmented effect of dairy vs. supplemental calcium is likely attributable to additional bioactive compounds in dairy that act synergistically with calcium to attenuate adiposity; among these are angiotensin converting enzyme inhibitory peptides, which limit angiotensin II production and thereby limit angiotensin II stimulation of adipocyte lipogenesis. These concepts are confirmed by both epidemiological and clinical data, which similarly demonstrate that dairy products exert a substantially greater effect on both fat loss and fat distribution compared to an equivalent amount of supplemental calcium.
Publication Types:
Review
Review, Tutorial
PMID: 12514303 [PubMed - indexed for MEDLINE]
in pratica: diete con alto introito di calcio favoriscono termogenesi e lipolisi bloccando la lipogenesi.
nella seconda parte spiega che assumendo alimenti ricchi di calcio (I LATTICINI CHE MOLTI LEVANO IN DEFINIZIONE) si ha un effetto lipolitico della madonna, riscontrato in maniera minore se si integra.
Ne avevo trovati altri ma grazie ai continui messaggi di joe li ho persi.
in poche parole:
- su con il calcio!!!!
- assumere latticini, e cmq prodotti ad alto contenuto di calcio aiuta il dimagrimento e non poco, al di la dell'eventuale ritenzione (che tanto chi ***** se ne freca.)
- l'integrazione di calcio co pasticche pasticcone non e' efficace come con gli alimenti grazie alla presenza di enzimi
- assumere calcio c'e' da farlo lontano da fonti di caffeina che ne inibirebbe l'assorbimento
- viceversa, assumere multivitaminici multiminerali lontano dal calcio perche il calcio stesso ne limiterebbe l'abs.
- ci sono gli studi anche sulle persone e non solo sui topi...
- c'e' uno studio che dice che le diete iperproteiche portano alla deplezione de calcio... quindi assumerlo non puo' fare che bene
- e non solo! il calcio combatte pure L'INSULINO RESISTENZA!
... daje dentro co la vanetta
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