continua il mio studio sulla caffeina.
ho trovato un cosino degno di nota:
1: Biochem J 1982 Apr 15;204(1):257-64 Related Articles, Links
The effects of calcium on protein turnover in skeletal muscles of the rat.
Lewis SE, Anderson P, Goldspink DF.
Several experimental procedures were used to increase the intracellular concentration of Ca2+ and determine its effects on protein turnover in isolated extensor digitorum longus and soleus muscle. These methods included the use of ionophore A23187, caffeine, dibucaine, thymol and procaine, all agents known to induce the release of calcium by acting either on the sarcolemma and/or on the sarcoplasmic reticulum. Another approach involved varying the external concentration of Ca2+ in the media in which the muscles were incubated. The changes in muscle Ca2+ concentrations after exposure to the various calcium-releasing agents were in keeping with accepted modes of action of these agents on muscle membranes. The findings suggest that increasing the sarcoplasmic concentration of Ca2+ inhibits protein synthesis and enhances protein breakdown. These catabolic effects of Ca2+ are compared with the changes induced in muscle protein turnover after exposure to insulin or cyclic nucleotides, and in myopathic muscle and situations of work overload. Attention is also drawn to some of the difficulties involved in definitively implicating Ca2+ as a factor involved in the normal regulation of protein turnover.
PMID: 6288015 [PubMed - indexed for MEDLINE]
in pratica la caffeina libera ioni di calcio dai muscoli, i quali hanno effetto catabolico e chiaramente negativo nel turnover proteico.
(il calcio e' fondamentale per la sintesi proteica e la contrazione muscolare, ecco perche mi in***** con chi leva latticini)
se poi utilizzate anche creatina et cazzimma varia il calcio va in crisi.
NON SOTTOVALUTATELO! se non vi va giu, al supermercato ci sono ottimi integratori di calcio e D3.
viceversa, ecco uno studietto per chi soffre di herpes.
Intervirology 1988;29(4):235-40 Related Articles, Links
Effects of caffeine on herpes simplex virus.
Shiraki K, Rapp F.
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey 17033.
At concentrations greater than 1 mg/ml, caffeine inhibited plaque formation by herpes simplex virus type 1 (HSV-1), suppressed growth of HSV-1 at various steps of the replicative cycle, but did not inactivate virus infectivity. These effects were independent of each other and persisted through completion of virus replication, as determined by one-step growth studies. Some replication steps appeared to recover after removal of caffeine. Strong inhibition of the spread of HSV by caffeine also was demonstrated by infectious center assay. Caffeine suppressed protein synthesis, in particular that of three viral proteins.
PMID: 2846467 [PubMed - indexed for MEDLINE]
in pratica dice che l'herpes e' inibito da una buona concentrazione di caffeina, per lo meno in vitro.
ho trovato un cosino degno di nota:
1: Biochem J 1982 Apr 15;204(1):257-64 Related Articles, Links
The effects of calcium on protein turnover in skeletal muscles of the rat.
Lewis SE, Anderson P, Goldspink DF.
Several experimental procedures were used to increase the intracellular concentration of Ca2+ and determine its effects on protein turnover in isolated extensor digitorum longus and soleus muscle. These methods included the use of ionophore A23187, caffeine, dibucaine, thymol and procaine, all agents known to induce the release of calcium by acting either on the sarcolemma and/or on the sarcoplasmic reticulum. Another approach involved varying the external concentration of Ca2+ in the media in which the muscles were incubated. The changes in muscle Ca2+ concentrations after exposure to the various calcium-releasing agents were in keeping with accepted modes of action of these agents on muscle membranes. The findings suggest that increasing the sarcoplasmic concentration of Ca2+ inhibits protein synthesis and enhances protein breakdown. These catabolic effects of Ca2+ are compared with the changes induced in muscle protein turnover after exposure to insulin or cyclic nucleotides, and in myopathic muscle and situations of work overload. Attention is also drawn to some of the difficulties involved in definitively implicating Ca2+ as a factor involved in the normal regulation of protein turnover.
PMID: 6288015 [PubMed - indexed for MEDLINE]
in pratica la caffeina libera ioni di calcio dai muscoli, i quali hanno effetto catabolico e chiaramente negativo nel turnover proteico.
(il calcio e' fondamentale per la sintesi proteica e la contrazione muscolare, ecco perche mi in***** con chi leva latticini)
se poi utilizzate anche creatina et cazzimma varia il calcio va in crisi.
NON SOTTOVALUTATELO! se non vi va giu, al supermercato ci sono ottimi integratori di calcio e D3.
viceversa, ecco uno studietto per chi soffre di herpes.
Intervirology 1988;29(4):235-40 Related Articles, Links
Effects of caffeine on herpes simplex virus.
Shiraki K, Rapp F.
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey 17033.
At concentrations greater than 1 mg/ml, caffeine inhibited plaque formation by herpes simplex virus type 1 (HSV-1), suppressed growth of HSV-1 at various steps of the replicative cycle, but did not inactivate virus infectivity. These effects were independent of each other and persisted through completion of virus replication, as determined by one-step growth studies. Some replication steps appeared to recover after removal of caffeine. Strong inhibition of the spread of HSV by caffeine also was demonstrated by infectious center assay. Caffeine suppressed protein synthesis, in particular that of three viral proteins.
PMID: 2846467 [PubMed - indexed for MEDLINE]
in pratica dice che l'herpes e' inibito da una buona concentrazione di caffeina, per lo meno in vitro.
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