...........2a parte........
Let's go to something totally different, a lady with severe osteoporosis. She is almost three standard deviations below the norm in both the hip femeral neck and the cervical vertebrae, and she is very worried about getting a fracture. A fairly young woman and she was put on a high carbohydrate diet and told that would be of benefit, and placed on estrogen, which is a fairly typical treatment. They wanted to put her on some other medicines and she didn't want to, she wanted to know if there was an alternative. Although we didn't have as dramatic a turn around, we got her to one standard deviation below the norm in a year, taking her off the estrogen she was on, anyway.
Let's go to calaudication. That is severe angina of the leg when you walk, same thing as angina of the heart except of the leg. While walking, after walking a certain distance, there is pain. There was a gentleman who had extremely severe calaudication, who happens to be my stepfather. It was a typical case, he would walk about fifty yards and then he would get severe, crampy pain in his legs. He was quite well off and was going to see the best doctors in Chicago, and they couldn't figure out what was wrong with him initially. He went to a neurologist, they thought it might be neurological pain or back pain. He finally went to a vascular surgeon who said he thought it was vascular disease, so they did an artheriogram and sure enough, he had severe vascular disease. They did Doppler studies on his anko-bracheal ratio on one side and it was 0.6, normal is around 1.1. 0.4 and you are in trouble for gangrene, so it was pretty bad, and they wanted to do the typical by-pass surgery that they normally do on this. He was thinking of going in for the surgery for one reason, they had a trip planned to Europe in two weeks, and he wanted to be able to walk since they normally do a lot of walking. Ten years previously he'd had an angioplasty for heart disease. At the time ten years ago, I told him he had to change his diet and he didn't of course. But this time he listened. I said that if he was not going to have a by-pass, then do exactly what I tell you to do and in two weeks you'll be walking just fine because by modulating this one aspect of his disease, I have never seen it not work, and it works very quickly to open up the artery.
We can talk about a patient with a very high cancer risk. She had a mother and a sister who both died of breast cancer and she didn't want to, so she came in and I put her on the exact same treatment as the other cases I just mentioned. They were all treated virtually identically because they all had the same thing wrong with them.
What would be the typical treatment of cardiovascular disease? First they check the cholesterol. High cholesterol over 200, they put you on cholesterol lowering drugs and what does it do? It shuts off your CoQ10. What does CoQ10 do? It is involved in the energy production and protection of little energy furnaces in every cell, so energy production goes way down. A common side effect of people who are on all these HMG co-enzyme reductase inhibitors is that they tell you their arms feel heavy. Well, the heart is a muscle too, and it's going to feel heavy too. One of the best treatments for a weak heart is CoQ10 for congestive heart failure. But they have no trouble shutting CoQ10 production off so that they can treat a number. And the common therapies for osteoporosis are drugs, and the common therapy for calaudication is surgery. For cancer reduction there is nothing. But all of these have a common cause.
The same cause as three major avenues of research in aging. One is called caloric restriction. There are thousands of studies done since the fifties on caloric restriction. They restrict calories of laboratory animals. They have known since the fifties that if you restrict calories but maintain a high level of nutrition, called "C.R.O.N.'s:" Caloric restriction with optimal nutrition, or adequate nutrition, which would be CRAN"S, these animals can live anywhere between thirty and two-hundred percent longer depending on the species. They've done it on several dozen species and the results are uniform throughout. They are doing it on primates now and it is working with primates, we won't know for sure for about another ten years, they are about half way through the experiment, our nearest relatives are also living much longer.
.............continua...........
Let's go to something totally different, a lady with severe osteoporosis. She is almost three standard deviations below the norm in both the hip femeral neck and the cervical vertebrae, and she is very worried about getting a fracture. A fairly young woman and she was put on a high carbohydrate diet and told that would be of benefit, and placed on estrogen, which is a fairly typical treatment. They wanted to put her on some other medicines and she didn't want to, she wanted to know if there was an alternative. Although we didn't have as dramatic a turn around, we got her to one standard deviation below the norm in a year, taking her off the estrogen she was on, anyway.
Let's go to calaudication. That is severe angina of the leg when you walk, same thing as angina of the heart except of the leg. While walking, after walking a certain distance, there is pain. There was a gentleman who had extremely severe calaudication, who happens to be my stepfather. It was a typical case, he would walk about fifty yards and then he would get severe, crampy pain in his legs. He was quite well off and was going to see the best doctors in Chicago, and they couldn't figure out what was wrong with him initially. He went to a neurologist, they thought it might be neurological pain or back pain. He finally went to a vascular surgeon who said he thought it was vascular disease, so they did an artheriogram and sure enough, he had severe vascular disease. They did Doppler studies on his anko-bracheal ratio on one side and it was 0.6, normal is around 1.1. 0.4 and you are in trouble for gangrene, so it was pretty bad, and they wanted to do the typical by-pass surgery that they normally do on this. He was thinking of going in for the surgery for one reason, they had a trip planned to Europe in two weeks, and he wanted to be able to walk since they normally do a lot of walking. Ten years previously he'd had an angioplasty for heart disease. At the time ten years ago, I told him he had to change his diet and he didn't of course. But this time he listened. I said that if he was not going to have a by-pass, then do exactly what I tell you to do and in two weeks you'll be walking just fine because by modulating this one aspect of his disease, I have never seen it not work, and it works very quickly to open up the artery.
We can talk about a patient with a very high cancer risk. She had a mother and a sister who both died of breast cancer and she didn't want to, so she came in and I put her on the exact same treatment as the other cases I just mentioned. They were all treated virtually identically because they all had the same thing wrong with them.
What would be the typical treatment of cardiovascular disease? First they check the cholesterol. High cholesterol over 200, they put you on cholesterol lowering drugs and what does it do? It shuts off your CoQ10. What does CoQ10 do? It is involved in the energy production and protection of little energy furnaces in every cell, so energy production goes way down. A common side effect of people who are on all these HMG co-enzyme reductase inhibitors is that they tell you their arms feel heavy. Well, the heart is a muscle too, and it's going to feel heavy too. One of the best treatments for a weak heart is CoQ10 for congestive heart failure. But they have no trouble shutting CoQ10 production off so that they can treat a number. And the common therapies for osteoporosis are drugs, and the common therapy for calaudication is surgery. For cancer reduction there is nothing. But all of these have a common cause.
The same cause as three major avenues of research in aging. One is called caloric restriction. There are thousands of studies done since the fifties on caloric restriction. They restrict calories of laboratory animals. They have known since the fifties that if you restrict calories but maintain a high level of nutrition, called "C.R.O.N.'s:" Caloric restriction with optimal nutrition, or adequate nutrition, which would be CRAN"S, these animals can live anywhere between thirty and two-hundred percent longer depending on the species. They've done it on several dozen species and the results are uniform throughout. They are doing it on primates now and it is working with primates, we won't know for sure for about another ten years, they are about half way through the experiment, our nearest relatives are also living much longer.
.............continua...........