La ricerca va avanti, sempre e comunque (se ci sono i soldi!)
Piazzo altra carne al fuoco ragazzi
.....fresca di un immane lavoro che ho in corso su vari fronti (mi servirebbe ormai una segretaria!LOL)...
Si sta cercando nuovi fronti di sviluppo oltre che conferma in merito alle integrazioni amminoacidiche.........quindi stay tuned.....
Ecco un paio di studi interessantissimi raccolti da una fonte prestigiosa, ora nel mondo dell'integrazione di nuova generazione......
(n.b. il primo studio è di Layne Norton.....)
LEGGETE BENE TUTTI I PASSAGGI!!! (inglese permettendo)
The true value of BCAAs supplementation is finally well established both in literature and in real world application: Anabolic (muscle building) stimuli is their true value rather than wasting good proteins to catabolism (muscle wasting) and more money landing in your toilet.
All amino acids are derived from the assimilation of proteins. BCAA’s are the branch chain amino acids Leucine, Valine and Isoleucine. BCAA’s are not only 3 of the paramount 18-22 essential amino acids (as in your body cannot make them and needs them to live) they alone also make up about 70% of your muscle cellular pool as well as cellular structure. Unfortunately BCAAs are lost (...muscle loss) at a rapid rate during any training and during calorie deficient diets. The result is less muscle and the need to replenish these muscle mainstays…or better yet, trigger an anabolic environment that fosters nutrient super-over-compensation where we need it: for accelerated muscular growth. Why else do we train?
In one excellent study it was shown that “Branched-chain amino acids activate key enzymes in protein synthesis after physical exercise”. J Nutr. 2006 Jan;136(1 Suppl):269S-73S researches again validated "BCAAs (leucine, isoleucine, and valine), particularly leucine, have anabolic effects on protein metabolism by increasing the rate of protein synthesis and decreasing the rate of protein degradation in resting human muscle."
In another study we find validation that “Leucine regulates translation initiation of protein synthesis in skeletal muscle after exercise”. J Nutr. 2006 Feb;136(2):533S-537S. Norton LE, Layman DK. Researchers validate the mechanism by which the anabolic signal is initiated: "High-performance physical activity and post-exercise recovery lead to significant changes in amino acid and protein metabolism in skeletal muscle. Central to these changes is an increase in the metabolism of the BCAA leucine. During exercise, muscle protein synthesis decreases together with a net increase in protein degradation and stimulation of BCAA oxidation. BCAA oxidation increases through activation of the branched-chain alpha-keto acid dehydrogenase (BCKDH). BCKDH activity increases with exercise, reducing plasma and intracellular leucine concentrations. After exercise, recovery of muscle protein synthesis requires dietary protein or BCAA to increase tissue levels of leucine in order to release the inhibition of the initiation factor 4 complex through activation of the protein kinase mammalian target of rapamycin (mTOR). Leucine's effect on mTOR is synergistic with insulin via the phosphoinositol 3-kinase signaling pathway. Together, insulin and leucine allow skeletal muscle to coordinate protein synthesis with physiological state and dietary intake."
Questo lo sapevamo già da tempo però.....era insieme all'altro e lo ricordiamo perchè IMPORTANTE!
An interesting study on BCAAs affects upon fatigue was conducted in Japan: First Department of Internal Medicine, Okayama University Medical School, 5-1, 2-chome, Shikata-cho, 700 Okayama, Japan
The molar ratio of excitatory amino acid neurotransmitters (glutamate and aspartate) to inhibitory amino acid neurotransmitters (raminobutyric acid, GABA, and glycine) in the brain was diminished in acute hepatic failure rats with hyperammonemia, brain edema, and abnormal electroencephalograms. The ratio was further decreased with a marked elevation of arterial and brain ammonia levels 30 min after ammonium acetate was administered i.p. to hepatic failure rats. A continuous infusion of a branched chain amino acid (BCAA) solution before and after the ammonia loading effectively reversed the ammonia-induced lowering of this ratio; high ammonia contents in the brain were concomitantly decreased. Infusing glutamate instead of the BCAA solution failed to produce similar effects probably because of limited entry of glutamate into the brain. The above results suggest that excitatory and inhibitory amino acid neurotransmitter ratios (glutamate, aspartate, and GABA) are positively affected by BCAAs. In short, BCAA supplementation reduced brain/physical fatigue.
So more muscle and better performance if we simply don’t mix glutamine with BCAAs.Glutamine is paramount to health and recovery, but timing is everything.
Piazzo altra carne al fuoco ragazzi
.....fresca di un immane lavoro che ho in corso su vari fronti (mi servirebbe ormai una segretaria!LOL)...Si sta cercando nuovi fronti di sviluppo oltre che conferma in merito alle integrazioni amminoacidiche.........quindi stay tuned.....
Ecco un paio di studi interessantissimi raccolti da una fonte prestigiosa, ora nel mondo dell'integrazione di nuova generazione......
(n.b. il primo studio è di Layne Norton.....)
LEGGETE BENE TUTTI I PASSAGGI!!! (inglese permettendo)
The true value of BCAAs supplementation is finally well established both in literature and in real world application: Anabolic (muscle building) stimuli is their true value rather than wasting good proteins to catabolism (muscle wasting) and more money landing in your toilet.
All amino acids are derived from the assimilation of proteins. BCAA’s are the branch chain amino acids Leucine, Valine and Isoleucine. BCAA’s are not only 3 of the paramount 18-22 essential amino acids (as in your body cannot make them and needs them to live) they alone also make up about 70% of your muscle cellular pool as well as cellular structure. Unfortunately BCAAs are lost (...muscle loss) at a rapid rate during any training and during calorie deficient diets. The result is less muscle and the need to replenish these muscle mainstays…or better yet, trigger an anabolic environment that fosters nutrient super-over-compensation where we need it: for accelerated muscular growth. Why else do we train?
What Does The Research Say?
In one excellent study it was shown that “Branched-chain amino acids activate key enzymes in protein synthesis after physical exercise”. J Nutr. 2006 Jan;136(1 Suppl):269S-73S researches again validated "BCAAs (leucine, isoleucine, and valine), particularly leucine, have anabolic effects on protein metabolism by increasing the rate of protein synthesis and decreasing the rate of protein degradation in resting human muscle."
In another study we find validation that “Leucine regulates translation initiation of protein synthesis in skeletal muscle after exercise”. J Nutr. 2006 Feb;136(2):533S-537S. Norton LE, Layman DK. Researchers validate the mechanism by which the anabolic signal is initiated: "High-performance physical activity and post-exercise recovery lead to significant changes in amino acid and protein metabolism in skeletal muscle. Central to these changes is an increase in the metabolism of the BCAA leucine. During exercise, muscle protein synthesis decreases together with a net increase in protein degradation and stimulation of BCAA oxidation. BCAA oxidation increases through activation of the branched-chain alpha-keto acid dehydrogenase (BCKDH). BCKDH activity increases with exercise, reducing plasma and intracellular leucine concentrations. After exercise, recovery of muscle protein synthesis requires dietary protein or BCAA to increase tissue levels of leucine in order to release the inhibition of the initiation factor 4 complex through activation of the protein kinase mammalian target of rapamycin (mTOR). Leucine's effect on mTOR is synergistic with insulin via the phosphoinositol 3-kinase signaling pathway. Together, insulin and leucine allow skeletal muscle to coordinate protein synthesis with physiological state and dietary intake."
Questo lo sapevamo già da tempo però.....era insieme all'altro e lo ricordiamo perchè IMPORTANTE!
An interesting study on BCAAs affects upon fatigue was conducted in Japan: First Department of Internal Medicine, Okayama University Medical School, 5-1, 2-chome, Shikata-cho, 700 Okayama, Japan
The molar ratio of excitatory amino acid neurotransmitters (glutamate and aspartate) to inhibitory amino acid neurotransmitters (raminobutyric acid, GABA, and glycine) in the brain was diminished in acute hepatic failure rats with hyperammonemia, brain edema, and abnormal electroencephalograms. The ratio was further decreased with a marked elevation of arterial and brain ammonia levels 30 min after ammonium acetate was administered i.p. to hepatic failure rats. A continuous infusion of a branched chain amino acid (BCAA) solution before and after the ammonia loading effectively reversed the ammonia-induced lowering of this ratio; high ammonia contents in the brain were concomitantly decreased. Infusing glutamate instead of the BCAA solution failed to produce similar effects probably because of limited entry of glutamate into the brain. The above results suggest that excitatory and inhibitory amino acid neurotransmitter ratios (glutamate, aspartate, and GABA) are positively affected by BCAAs. In short, BCAA supplementation reduced brain/physical fatigue.
So more muscle and better performance if we simply don’t mix glutamine with BCAAs.Glutamine is paramount to health and recovery, but timing is everything.
perchè nel post mario?
Commenta